Chemical Character and Physiological Action of the Potassium Ion

1. It is shown that the NH(4) ion acts in cases of antagonism on the egg of Fundulus more like the K ion than the Na ion; this corresponds to the fact that in its general chemical behavior the NH(4) ion resembles the K ion more closely than the Na ion. 2. It is shown that the tolerance of sea urchin eggs towards the Li ion can be increased 500 per cent or more if at the same time a certain amount of Na ion is replaced by K, Rb, or Cs ions. Since in the periodic table Na occupies a position between K and Li it is inferred that the Li and K ions deviate in their physiological action in the opposite direction from the Na ion. 3. These data indicate that the behavior of the K ion in antagonistic salt action (which forms the basis of the physiologically balanced action of ions) is due to its purely chemical character, i.e. its position in the periodic table or rather to its atomic number, and not to those explosions in its nucleus which give rise to a trace of radioactivity.